Result
Related information of protein
Organism | Homo sapiens |
UniProt ID | Q9UHC9 |
Gene name | NPC1L1 |
Protein name | NPC1-like intracellular cholesterol transporter 1 |
Function | Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation. |
Sequence | MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSNTPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGVARCNESQGDDVATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTILLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALALSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDWLTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVNLTSDGQVLDTVAILSPRLEYSGTISAHCNLYLLDSTSRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPALALEQKRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEGSIKGAGAISNFLPNNGRQF |
Cysteine modification and structural characteristics
Detailed information on cysteine modification
Uniprot ID | Gene name | Position | Sequence window | Modification | Source |
---|---|---|---|---|---|
Q9UHC9 | NPC1L1 | 33 | TIHQPGYCAFYDECG | Disulfide bond (-SSR) | UniProt |
Q9UHC9 | NPC1L1 | 39 | YCAFYDECGKNPELS | Disulfide bond (-SSR) | UniProt |
Q9UHC9 | NPC1L1 | 57 | MTLSNVSCLSNTPAR | Disulfide bond (-SSR) | UniProt |
Q9UHC9 | NPC1L1 | 78 | LILLQKICPRLYTGP | Disulfide bond (-SSR) | UniProt |
Q9UHC9 | NPC1L1 | 90 | TGPNTQACCSAKQLV | Disulfide bond (-SSR) | UniProt |
Q9UHC9 | NPC1L1 | 91 | GPNTQACCSAKQLVS | Disulfide bond (-SSR) | UniProt |
Q9UHC9 | NPC1L1 | 113 | TKALLTRCPACSDNF | Disulfide bond (-SSR) | UniProt |
Q9UHC9 | NPC1L1 | 116 | LLTRCPACSDNFVNL | Disulfide bond (-SSR) | UniProt |
Q9UHC9 | NPC1L1 | 125 | DNFVNLHCHNTCSPN | Disulfide bond (-SSR) | UniProt |
Q9UHC9 | NPC1L1 | 129 | NLHCHNTCSPNQSLF | Disulfide bond (-SSR) | UniProt |
Q9UHC9 | NPC1L1 | 172 | AEQSYDSCSRVRVPA | Disulfide bond (-SSR) | UniProt |
Q9UHC9 | NPC1L1 | 189 | TLAVGTMCGVYGSAL | Disulfide bond (-SSR) | UniProt |
Q9UHC9 | NPC1L1 | 197 | GVYGSALCNAQRWLN | Disulfide bond (-SSR) | UniProt |
Q9UHC9 | NPC1L1 | 243 | LNEGVARCNESQGDD | Disulfide bond (-SSR) | UniProt |
Q9UHC9 | NPC1L1 | 254 | QGDDVATCSCQDCAA | Disulfide bond (-SSR) | UniProt |
Q9UHC9 | NPC1L1 | 256 | DDVATCSCQDCAASC | Disulfide bond (-SSR) | UniProt |
Q9UHC9 | NPC1L1 | 259 | ATCSCQDCAASCPAI | Disulfide bond (-SSR) | UniProt |
Q9UHC9 | NPC1L1 | 263 | CQDCAASCPAIARPQ | Disulfide bond (-SSR) | UniProt |